There are
2,112 mi
from San Marcos, CA to Jeffersonville, IN
That's the driving distance. It would take 1 day 13 hours to go from San Marcos, California to Jeffersonville, Indiana.
The flight distance (direct flight from San Marcos, CA to Jeffersonville, IN) is 1,789.55 mi.
2,112 mi = 3.22 kms