There are
2,126 mi
from San Leandro, CA to Sikeston, MO
That's the driving distance. It would take 1 day 13 hours to go from San Leandro, California to Sikeston, Missouri.
The flight distance (direct flight from San Leandro, CA to Sikeston, MO) is 1,781.88 mi.
2,126 mi = 3.22 kms