There are
2,083 mi
from San Leandro, CA to Opelousas, LA
That's the driving distance. It would take 1 day 12 hours to go from San Leandro, California to Opelousas, Louisiana.
The flight distance (direct flight from San Leandro, CA to Opelousas, LA) is 1,781.72 mi.
2,083 mi = 3.22 kms