There are
627 mi
from San Leandro, CA to Mesquite, NV
That's the driving distance. It would take 11 hours 28 mins to go from San Leandro, California to Mesquite, Nevada.
The flight distance (direct flight from San Leandro, CA to Mesquite, NV) is 449.16 mi.
627 mi = 1,009.20 kms