There are
2,660 mi
from San Leandro, CA to Cayce, SC
That's the driving distance. It would take 1 day 22 hours to go from San Leandro, California to Cayce, South Carolina.
The flight distance (direct flight from San Leandro, CA to Cayce, SC) is 2,297.10 mi.
2,660 mi = 4,281.21 kms