There are
2,191 mi
from San Jose, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 14 hours to go from San Jose, California to Cape Girardeau, Missouri.
The flight distance (direct flight from San Jose, CA to Cape Girardeau, MO) is 1,770.09 mi.
2,191 mi = 3.22 kms