There are
1,740 mi
from San Francisco, CA to Sioux Falls, SD
That's the driving distance. It would take 1 day 5 hours to go from San Francisco, California to Sioux Falls, South Dakota.
The flight distance (direct flight from San Francisco, CA to Sioux Falls, SD) is 1,399.35 mi.
1,740 mi = 1.61 kms