There are
2,200 mi
from San Diego, CA to Knoxville, TN
That's the driving distance. It would take 1 day 14 hours to go from San Diego, California to Knoxville, Tennessee.
The flight distance (direct flight from San Diego, CA to Knoxville, TN) is 1,900.22 mi.
2,200 mi = 3.22 kms