There are
368 mi
from San Clemente, CA to Mesquite, NV
That's the driving distance. It would take 6 hours 45 mins to go from San Clemente, California to Mesquite, Nevada.
The flight distance (direct flight from San Clemente, CA to Mesquite, NV) is 307.57 mi.
368 mi = 592.17 kms