There are
1,897 mi
from San Clemente, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 9 hours to go from San Clemente, California to Cape Girardeau, Missouri.
The flight distance (direct flight from San Clemente, CA to Cape Girardeau, MO) is 1,599.36 mi.
1,897 mi = 3,052.16 kms