There are
305 mi
from San Bernardino, CA to Mesquite, NV
That's the driving distance. It would take 5 hours 27 mins to go from San Bernardino, California to Mesquite, Nevada.
The flight distance (direct flight from San Bernardino, CA to Mesquite, NV) is 260.03 mi.
305 mi = 491.19 kms