There are
879 mi
from San Angelo, TX to Cape Girardeau, MO
That's the driving distance. It would take 15 hours 23 mins to go from San Angelo, Texas to Cape Girardeau, Missouri.
The flight distance (direct flight from San Angelo, TX to Cape Girardeau, MO) is 741.20 mi.
879 mi = 1,415.14 kms