There are
653 mi
from Saginaw, MI to Sikeston, MO
That's the driving distance. It would take 12 hours 2 mins to go from Saginaw, Michigan to Sikeston, Missouri.
The flight distance (direct flight from Saginaw, MI to Sikeston, MO) is 540.98 mi.
653 mi = 1,050.92 kms