There are
628 mi
from Saginaw, MI to Cape Girardeau, MO
That's the driving distance. It would take 11 hours 43 mins to go from Saginaw, Michigan to Cape Girardeau, Missouri.
The flight distance (direct flight from Saginaw, MI to Cape Girardeau, MO) is 513.86 mi.
628 mi = 1,011.33 kms