There are
446 mi
from Roswell, GA to Cape Girardeau, MO
That's the driving distance. It would take 8 hours 42 mins to go from Roswell, Georgia to Cape Girardeau, Missouri.
The flight distance (direct flight from Roswell, GA to Cape Girardeau, MO) is 367.63 mi.
446 mi = 717.99 kms