There are
301 mi
from Rockville, MD to Poughkeepsie, NY
That's the driving distance. It would take 6 hours 13 mins to go from Rockville, Maryland to Poughkeepsie, New York.
The flight distance (direct flight from Rockville, MD to Poughkeepsie, NY) is 248.16 mi.
301 mi = 484.03 kms