There are
408 mi
from Rockford, IL to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 33 mins to go from Rockford, Illinois to Cape Girardeau, Missouri.
The flight distance (direct flight from Rockford, IL to Cape Girardeau, MO) is 343.80 mi.
408 mi = 657.32 kms