There are
726 mi
from Rock Hill, SC to Poughkeepsie, NY
That's the driving distance. It would take 14 hours 4 mins to go from Rock Hill, South Carolina to Poughkeepsie, New York.
The flight distance (direct flight from Rock Hill, SC to Poughkeepsie, NY) is 605.74 mi.
726 mi = 1,168.57 kms