There are
727 mi
from Rock Hill, SC to Poughkeepsie, NY
That's the driving distance. It would take 14 hours 17 mins to go from Rock Hill, South Carolina to Poughkeepsie, New York.
The flight distance (direct flight from Rock Hill, SC to Poughkeepsie, NY) is 605.74 mi.
727 mi = 1,170.68 kms