There are
727 mi
from Roanoke, VA to Zephyrhills, FL
That's the driving distance. It would take 14 hours 13 mins to go from Roanoke, Virginia to Zephyrhills, Florida.
The flight distance (direct flight from Roanoke, VA to Zephyrhills, FL) is 637.78 mi.
727 mi = 1,170.49 kms