There are
798 mi
from Roanoke, VA to Yazoo City, MS
That's the driving distance. It would take 14 hours 42 mins to go from Roanoke, Virginia to Yazoo City, Mississippi.
The flight distance (direct flight from Roanoke, VA to Yazoo City, MS) is 665.25 mi.
798 mi = 1,284.04 kms