There are
272 mi
from Roanoke, VA to Waynesville, NC
That's the driving distance. It would take 5 hours 16 mins to go from Roanoke, Virginia to Waynesville, North Carolina.
The flight distance (direct flight from Roanoke, VA to Waynesville, NC) is 209.50 mi.
272 mi = 438.45 kms