There are
2,736 mi
from Roanoke, VA to South San Francisco, CA
That's the driving distance. It would take 2 days to go from Roanoke, Virginia to South San Francisco, California.
The flight distance (direct flight from Roanoke, VA to South San Francisco, CA) is 2,308.75 mi.
2,736 mi = 4,402.49 kms