There are
1,648 mi
from Roanoke, VA to Santa Fe, NM
That's the driving distance. It would take 1 day 5 hours to go from Roanoke, Virginia to Santa Fe, New Mexico.
The flight distance (direct flight from Roanoke, VA to Santa Fe, NM) is 1,443.87 mi.
1,648 mi = 1.61 kms