There are
2,702 mi
from Roanoke, VA to Santa Cruz, CA
That's the driving distance. It would take 1 day 23 hours to go from Roanoke, Virginia to Santa Cruz, California.
The flight distance (direct flight from Roanoke, VA to Santa Cruz, CA) is 2,299.25 mi.
2,702 mi = 4,348.94 kms