There are
2,733 mi
from Roanoke, VA to San Mateo, CA
That's the driving distance. It would take 2 days to go from Roanoke, Virginia to San Mateo, California.
The flight distance (direct flight from Roanoke, VA to San Mateo, CA) is 2,305.77 mi.
2,733 mi = 3.22 kms