There are
809 mi
from Roanoke, VA to Picayune, MS
That's the driving distance. It would take 14 hours 48 mins to go from Roanoke, Virginia to Picayune, Mississippi.
The flight distance (direct flight from Roanoke, VA to Picayune, MS) is 726.66 mi.
809 mi = 1,302.23 kms