There are
2,191 mi
from Roanoke, VA to Mesquite, NV
That's the driving distance. It would take 1 day 15 hours to go from Roanoke, Virginia to Mesquite, Nevada.
The flight distance (direct flight from Roanoke, VA to Mesquite, NV) is 1,872.07 mi.
2,191 mi = 3.22 kms