Miles between Roanoke, VA and Lancaster, SC

There are
220 mi
from Roanoke, VA to Lancaster, SC

That's the driving distance. It would take 4 hours 46 mins to go from Roanoke, Virginia to Lancaster, South Carolina.

The flight distance (direct flight from Roanoke, VA to Lancaster, SC) is 182.23 mi.

220 mi = 353.97 kms