There are
287 mi
from Roanoke, VA to Chillicothe, OH
That's the driving distance. It would take 5 hours 55 mins to go from Roanoke, Virginia to Chillicothe, Ohio.
The flight distance (direct flight from Roanoke, VA to Chillicothe, OH) is 217.89 mi.
287 mi = 462.06 kms