There are
371 mi
from Roanoke, VA to Chattanooga, TN
That's the driving distance. It would take 6 hours 51 mins to go from Roanoke, Virginia to Chattanooga, Tennessee.
The flight distance (direct flight from Roanoke, VA to Chattanooga, TN) is 336.56 mi.
371 mi = 596.63 kms