There are
923 mi
from Roanoke, VA to Carthage, MO
That's the driving distance. It would take 17 hours 22 mins to go from Roanoke, Virginia to Carthage, Missouri.
The flight distance (direct flight from Roanoke, VA to Carthage, MO) is 789.80 mi.
923 mi = 1,485.05 kms