There are
678 mi
from Roanoke, VA to Cahokia, IL
That's the driving distance. It would take 12 hours 59 mins to go from Roanoke, Virginia to Cahokia, Illinois.
The flight distance (direct flight from Roanoke, VA to Cahokia, IL) is 565.47 mi.
678 mi = 1,091.15 kms