There are
1,523 mi
from Reno, NV to Sioux Falls, SD
That's the driving distance. It would take 1 day 1 hour to go from Reno, Nevada to Sioux Falls, South Dakota.
The flight distance (direct flight from Reno, NV to Sioux Falls, SD) is 1,222.90 mi.
1,523 mi = 1.61 kms