There are
1,974 mi
from Reno, NV to Sikeston, MO
That's the driving distance. It would take 1 day 9 hours to go from Reno, Nevada to Sikeston, Missouri.
The flight distance (direct flight from Reno, NV to Sikeston, MO) is 1,643.57 mi.
1,974 mi = 1.61 kms