There are
2,596 mi
from Reno, NV to Lexington, SC
That's the driving distance. It would take 1 day 21 hours to go from Reno, Nevada to Lexington, South Carolina.
The flight distance (direct flight from Reno, NV to Lexington, SC) is 2,152.87 mi.
2,596 mi = 3.22 kms