There are
2,590 mi
from Reno, NV to Cayce, SC
That's the driving distance. It would take 1 day 21 hours to go from Reno, Nevada to Cayce, South Carolina.
The flight distance (direct flight from Reno, NV to Cayce, SC) is 2,161.91 mi.
2,590 mi = 3.22 kms