There are
1,944 mi
from Reno, NV to Cape Girardeau, MO
That's the driving distance. It would take 1 day 9 hours to go from Reno, Nevada to Cape Girardeau, Missouri.
The flight distance (direct flight from Reno, NV to Cape Girardeau, MO) is 1,639.47 mi.
1,944 mi = 1.61 kms