There are
1,057 mi
from Rapid City, SD to Cape Girardeau, MO
That's the driving distance. It would take 18 hours 30 mins to go from Rapid City, South Dakota to Cape Girardeau, Missouri.
The flight distance (direct flight from Rapid City, SD to Cape Girardeau, MO) is 855.67 mi.
1,057 mi = 1,700.56 kms