There are
309 mi
from Rancho Cucamonga, CA to Mesquite, NV
That's the driving distance. It would take 5 hours 32 mins to go from Rancho Cucamonga, California to Mesquite, Nevada.
The flight distance (direct flight from Rancho Cucamonga, CA to Mesquite, NV) is 272.28 mi.
309 mi = 496.77 kms