There are
743 mi
from Raleigh, NC to Sikeston, MO
That's the driving distance. It would take 13 hours 55 mins to go from Raleigh, North Carolina to Sikeston, Missouri.
The flight distance (direct flight from Raleigh, NC to Sikeston, MO) is 613.92 mi.
743 mi = 1,195.85 kms