There are
749 mi
from Raleigh, NC to Cape Girardeau, MO
That's the driving distance. It would take 14 hours 14 mins to go from Raleigh, North Carolina to Cape Girardeau, Missouri.
The flight distance (direct flight from Raleigh, NC to Cape Girardeau, MO) is 612.82 mi.
749 mi = 1,205.23 kms