There are
1,221 mi
from Port St Lucie, FL to Tahlequah, OK
That's the driving distance. It would take 22 hours 55 mins to go from Port St Lucie, Florida to Tahlequah, Oklahoma.
The flight distance (direct flight from Port St Lucie, FL to Tahlequah, OK) is 1,045 mi.
1,221 mi = 1.61 kms