Miles between Port St Lucie, FL and Simpsonville, SC

There are
608 mi
from Port St Lucie, FL to Simpsonville, SC

That's the driving distance. It would take 11 hours 6 mins to go from Port St Lucie, Florida to Simpsonville, South Carolina.

The flight distance (direct flight from Port St Lucie, FL to Simpsonville, SC) is 527.62 mi.

608 mi = 978.93 kms