There are
996 mi
from Port St Lucie, FL to Seymour, IN
That's the driving distance. It would take 18 hours 37 mins to go from Port St Lucie, Florida to Seymour, Indiana.
The flight distance (direct flight from Port St Lucie, FL to Seymour, IN) is 868 mi.
996 mi = 1,602.34 kms