Miles between Port St Lucie, FL and Orangeburg, SC

There are
485 mi
from Port St Lucie, FL to Orangeburg, SC

That's the driving distance. It would take 8 hours 52 mins to go from Port St Lucie, Florida to Orangeburg, South Carolina.

The flight distance (direct flight from Port St Lucie, FL to Orangeburg, SC) is 430.52 mi.

485 mi = 781.29 kms