There are
677 mi
from Port St Lucie, FL to Northport, AL
That's the driving distance. It would take 13 hours 4 mins to go from Port St Lucie, Florida to Northport, Alabama.
The flight distance (direct flight from Port St Lucie, FL to Northport, AL) is 595.48 mi.
677 mi = 1,090.18 kms