Miles between Port St Lucie, FL and North Charleston, SC

There are
472 mi
from Port St Lucie, FL to North Charleston, SC

That's the driving distance. It would take 8 hours 54 mins to go from Port St Lucie, Florida to North Charleston, South Carolina.

The flight distance (direct flight from Port St Lucie, FL to North Charleston, SC) is 386.13 mi.

472 mi = 759.88 kms