Miles between Port St Lucie, FL and Mt Pleasant, SC

There are
478 mi
from Port St Lucie, FL to Mt Pleasant, SC

That's the driving distance. It would take 9 hours 6 mins to go from Port St Lucie, Florida to Mt Pleasant, South Carolina.

The flight distance (direct flight from Port St Lucie, FL to Mt Pleasant, SC) is 382.41 mi.

478 mi = 768.93 kms