Miles between Port St Lucie, FL and Lancaster, SC

There are
582 mi
from Port St Lucie, FL to Lancaster, SC

That's the driving distance. It would take 10 hours 45 mins to go from Port St Lucie, Florida to Lancaster, South Carolina.

The flight distance (direct flight from Port St Lucie, FL to Lancaster, SC) is 514.96 mi.

582 mi = 936.33 kms