Miles between Port St Lucie, FL and Knoxville, TN

There are
754 mi
from Port St Lucie, FL to Knoxville, TN

That's the driving distance. It would take 13 hours 53 mins to go from Port St Lucie, Florida to Knoxville, Tennessee.

The flight distance (direct flight from Port St Lucie, FL to Knoxville, TN) is 635.53 mi.

754 mi = 1,212.99 kms